Supplementation of folic acid in pregnancy and the risk of preeclampsia and gestational hypertension: A meta-analysis
The relationship between #folicacid supplementation in pregnancy and risk of #preeclampsia and #gestationalhypertension was systematically assessed. Researchers analyzed 13 cohort studies and 1 randomized controlled trial study, containing 160,562 and 149,320 women with and without folic acid supplementation during pregnancy. Findings indicate significantly lower preeclampsia risk in association with the supplementation of #multivitamins containing folic acid during pregnancy.
Experts studied the impact of maternal folic acid supplementation during pregnancy on the risk of preeclampsia and gestational hypertension through a systematic review and meta-analysis. They searched multiple scientific databases and grey literature for relevant studies. According to pre-specified inclusion and exclusion criteria, studies were reviewed. They found low level evidence for a modest relationship between maternal folic acid supplementation and reduction in preeclampsia risk.
In total, 13 cohort studies and 1 randomized controlled trial study was included, containing 160,562 and 149,320 women with and without folic acid supplementation during pregnancy. Pooled results showed that risk of gestational hypertension was not associated with the supplementation of folic acid. However, folic acid supplementation during pregnancy could significantly reduce the risk of preeclampsia. Moreover, the results of subgroup analysis showed that the decreased preeclampsia risk was associated with supplementation of multivitamins containing folic acid rather than folic acid alone.
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